1,6-Dibromohexane → HCID 22228022, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3.33 g of 3,4-bis-(tetrahydropyranyl-2'-oxy)-phenylacetylene in 20 ml of absolute tetrahydrofuran were added dropwise over 45 minutes at -78° to -70° C., while stirring in an atmosphere of dry nitrogen, 6.9 ml of n-butyllithium solution, and after one hour stirring at the same temperature 5.1 ml of 1,6-dibromohexane followed by 7 ml of absolute 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone were added dropwise. The mixture was stirred for 20 hours, allowed to warm to 0° C. and then worked up as described in Example 5e. By column chromatography with toluene/diisopropyl ether (10:1) 3.55 g of the title compound were obtained.

Provenance & Evidence