Imidazole → HCID 22839120, compound

HRID 1032804Notes

Reaction equation

HRID 1032804 reaction equation
[Si]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[O:17][Si](C(C)(C)C)(C)C)[CH:12]=O)(C(C)(C)C)(C)C.O[C:26]1[CH:27]=[C:28]([CH:31]=[CH:32][C:33]=1O)[CH:29]=[O:30].[C:35]([Si](C)(C)Cl)(C)([CH3:37])[CH3:36].N1C=CN=C1>>[OH:8][C:9]1[CH:10]=[C:11](/[CH:12]=[CH:36]\[CH2:35][CH2:37][CH2:31][CH2:32][CH2:33][CH2:26][C:27]#[C:28][CH2:29][OH:30])[CH:14]=[CH:15][C:16]=1[OH:17]

Participants

5

Reactant 4

HCID 795ImidazoleHCID 87683,4-DihydroxybenzaldehydeHCID 28928tert-Butyldimethylsilyl chlorideHCID 109374483,4-di(t-butyldimethylsiloxy)benzaldehyde

Product 1

HCID 22839120HCID 22839120, compound

Procedure

The 3,4-bis-(tert-butyldimethylsilyloxy)-benzaldehyde used in Example 23d as one of the starting materials was prepared by reacting 2.14 g of 3,4-dihydroxybenzaldehyde, 5.83 g of tert-butyldimethylchlorosilane and 2.58 g of imidazole in the manner described in Example 14c. Chromatography with petroleum ether/ether (6:1) yielded 3.57 g of the title compound in the form of crystals melting at 44°-46° C.

Workup

  1. customwas prepared

Sources & evidence

ORD record
ord-4eb727b96ec74d14b776c059c5580e16
Source dataset
uspto-grants-1990_09
Patent number
US04959391

Reaction notes

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