HCID 67822391, compound → HCID 67822702, compound

Participants

Reaction Steps

Compound 1 (0.89 g, 1.5 mmol) was stirred for 1 h in methanol (50 mL) with 10% Pd/C (90 mg) under hydrogen pressure of 50 psi. The mixture was filtered and evaporated in vacuo. The product was purified by chromatography on silica gel using light petroleum (b.p. 50°-70° C.)/ethyl acetate (2:5) as the eluent. The yield of yellowish oil was 0.40 g (48%). 1H NMR (CDCl3): k 3.56 (1H, s), 3.59 (8H, s), 3.71 (12H, s), 4.01 (6H, broad s), 7.05-7.14 (4H, m), 7.70 (2H, s).

Provenance & Evidence