反应详情

1,2,4-Triazole-3-thiol (49.0 g; 0.484 mol) and 86% potassium hydroxide (32.0 g; 0.484 mol) were dissolved in methanol (500 ml) and refluxed for 1 h. The solution was then evaporated to dryness, and the residue redissolved in methanol (500 ml). Cyclopentylmethyl methanesulfonate (86.0 g; 0.484 mol) was added, the solution stirred under reflux for 8 h, and at room temperature overnight. The solution was evaporated and the residue dissolved in ether (500 ml) and water (1 1). The aqueous layer was separated and extracted with another portion of ether (500 ml). The ether solutions were combined, washed with saturated brine (500 ml), dried (MgSO4), filtered and evaporated, to afford cyclopentylmethyl 1,2,4-triazol-3-yl sulfide (85.0 g; 96%) as a waxy, white solid. NMR - d(CDCl3 ; 60 MHz) 1.0-2.4 (10H, m), 3.2 (2H, d, J=7 Hz), 8.1 (1H, s) and 13.4 (1H, br s).

1. temperaturerefluxed for 1 h
2. customThe solution was then evaporated to dryness
3. dissolutionthe residue redissolved in methanol (500 ml)
4. temperatureunder reflux for 8 h
5. customat room temperature
6. customovernight
7. customThe solution was evaporated
8. dissolutionthe residue dissolved in ether (500 ml)
9. customThe aqueous layer was separated
10. extractionextracted with another portion of ether (500 ml)
11. washwashed with saturated brine (500 ml)
12. dry with materialdried (MgSO4)
13. filtrationfiltered
14. customevaporated