Sodium Methoxide → HCID 178420905, compound

Participants

Reaction Steps

Cyclopentylmethyl bromide (21 g; 0.13 mol) was added in one portion to 1,2,4-triazole-3-thiol (12.3 g; 0.12 mol) and sodium methoxide (7.1 g; 0.13 mol) in dry methanol (100 ml) under dry nitrogen. The mixture was stirred at room temperature for 3 days, refluxed for 3 h and evaporated. The residue was dissolved in ethyl acetate (200 ml) and water (100 ml), the organic phase separated, washed with water (100 ml), dried (Na2SO4), filtered and evaporated, to afford cyclopentylmethyl 1,2,4-triazol-3-yl sulfide (18.1 g; 82%) as a waxy, off-shite solid, m.p. 48°-55° C.

Provenance & Evidence