反应详情

温度

140 °C

A mixture of 3-nitro-5-ethyl-6-methylpyridin-2(1H)-one (0.91 g, 5.0 mmol) and phosphorus pentachloride (1.25 g, 6.0 mmol), under a nitrogen atmosphere, was heated at 140° C. for 0.5 hours. The cooled mixture was diluted with chloroform and ice water. The separated chloroform layer was then washed with water, saturated aqueous NaHCO3 and dried (Na2SO4). After filtering through a pad of charcoal, solvent was evaporated to yield 672 mg (67%) of product.

1. washThe separated chloroform layer was then washed with water, saturated aqueous NaHCO3
2. dry with materialdried (Na2SO4)
3. filtrationAfter filtering through a pad of charcoal, solvent
4. customwas evaporated