HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxy-3-nitro-5-ethyl-6-methylpyridine → 2-Methoxy-3-amino-5-ethyl-6-methylpyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxy-3-nitro-5-ethyl-6-methylpyridine | HCID 10465270 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Methoxy-3-amino-5-ethyl-6-methylpyridine | HCID 10374794 | 98% |
Reaction Steps
A solution of 2-methoxy-3-nitro-5-ethyl-6-methylpyridine (535 mg, 2.72 mmol) in methanol (8 mL) and tetrahydrofuran (8 mL) containing 5% palladium on carbon (83 mg) was hydrogenated at atmospheric pressure for 5 hours. The catalyst was filtered off the solvent evaporated to yield 436 mg (98%) of oily product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05308854 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-43607c74710f483782df876a5943b4f2 |
| Source note | uspto-grants-1994_05 |