Pyridinium chloride → HCID 19086253, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-t-butylthio-3-{[(benzoxazol-2-yl)amino]methyl}-5-ethyl-6-methylpyridine (78 mg, 0.22 mmol) and pyridine hydrochloride (325 mg, 2.81 mmol) was warmed in a pre-heated oil bath at 150° C. for 25 minutes. The mixture was cooled, diluted with water and the yellow precipitated product was collected by filtration. This residue was dissolved in methylene chloride, filtered through a pad of charcoal and then hexane was added and the methylene chloride boiled off as the product crystallized out to yield 42 mg (64%), m.p. 238°-240° C. Anal Calcd. for C16H17N3OS: C, 64.18; H, 5.72; N, 14.04. Found: C, 63.86; H, 5.69; N, 13.81.

Provenance & Evidence