反应详情

To a solution of crude 2-methoxy-3-(2-aminoethyl)-5-ethyl-6-methylpyridine (332 mg) in ethanol (7 mL) was added N-(carbethoxy) phthalimide (406 mg, 1.85 mmol). After stirring at ambient temperature for three hours the solvent was evaporated and the residue was chromatographed on silica gel by gradient elution with 20-100% ethyl acetate/hexane. The appropriate fractions were combined, the solvent evaporated and the residue triturated with hexane as the product slowly crystallized out to yield 202 mg of pure product, m.p. 77°-79° C.

1. customwas evaporated
2. customthe residue was chromatographed on silica gel by gradient elution with 20-100% ethyl acetate/hexane
3. customthe solvent evaporated
4. customthe residue triturated with hexane as the product
5. customslowly crystallized out