Sodium Dithionite → HCID 10012332, compound

Participants

Reaction Steps

To a mixture of 5-methylthio-6-methyl-3-nitropyridin-2(1H)-one (0.60 g, 0.003 mmol) in MeOH (30 mL) at room temperature was added an aqueous solution of sodium hydrosulfite (Na2S2O4) (1.74 g, 0.01 mol). When the yellow color disappeared after addition of additional sodium hydrosulfite (1.7 g), the reaction mixture was extracted with CHCl3 (2×200 mL). The CHCl3 extracts were washed with saturated aqueous NaHCO3 solution, brine and then dried (MgSO4). On concentration under vacuum there was obtained 0.20 g (39.4% yield) of 3-amino-5-methylthio-6-methylpyridin-2(1H)-one as a light yellow solid which was used without further purification.

Provenance & Evidence