Bromine → HCID 19086280, compound

HRID 1033041Notes

Reaction equation

HRID 1033041 reaction equation
[Br:1]Br.[C:3]([NH:6][C:7]([NH:9][CH2:10][C:11]1[O:12][C:13]([C:16](=[O:18])[CH3:17])=[CH:14][CH:15]=1)=[O:8])(=[O:5])[CH3:4]>ClCCl>[C:3]([NH:6][C:7]([NH:9][CH2:10][C:11]1[O:12][C:13]([C:16](=[O:18])[CH2:17][Br:1])=[CH:14][CH:15]=1)=[O:8])(=[O:5])[CH3:4]

Participants

4

Reactant 2

HCID 24408BromineHCID 19086315HCID 19086315, compound

Product 1

HCID 19086280HCID 19086280, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A solution of bromine (0.23 ml) in dichloromethane (5 ml) was dropwise added to a mixture of 1-acetyl-3-(5-acetylfuran-2-ylmethyl)urea (1.0 g) in dichloromethane (20 ml) at ambient temperature for 20 minutes and the mixture was stirred at the same temperature for 1.5 hours. The solvent was removed by concentration and residue was triturated with isopropyl ether to give 1-acetyl-3-[5-(bromoacetyl)furan-2-ylmethyl]urea (1.27 g).

Workup

  1. customThe solvent was removed by concentration and residue
  2. customwas triturated with isopropyl ether

Sources & evidence

ORD record
ord-5b34742520db4cf08dd088175c1341fb
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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