Sodium Hydroxide → HCID 10709059, compound

HRID 1033044Notes

Reaction equation

HRID 1033044 reaction equation
[OH-].[Na+].[C:3]([NH:6][CH2:7][C:8]1[O:12][C:11]([C:13]2[N:14]=[C:15]([NH:18][C:19]([NH:21]C(=O)C3C=CC=CC=3)=[S:20])[S:16][CH:17]=2)=[CH:10][CH:9]=1)(=[O:5])[CH3:4]>O.CO>[C:3]([NH:6][CH2:7][C:8]1[O:12][C:11]([C:13]2[N:14]=[C:15]([NH:18][C:19]([NH2:21])=[S:20])[S:16][CH:17]=2)=[CH:10][CH:9]=1)(=[O:5])[CH3:4]

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 10692374HCID 10692374, compound

Product 1

HCID 10709059HCID 10709059, compoundYield 73.8%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
60 °C

Procedure

A solution of sodium hydroxide (0.55 g) in water (5 ml) was added to a suspension of 4-(5-acetylaminomethylfuran-2-yl)-2-(3-benzoylthioureido)thiazole (5.40 g) in methanol (50 ml) and the mixture was stirred at 60° C. for two hours. Following evaporation in vacuo, the residue was mixed with water (50 ml) and ethyl acetate (15 ml) and stirred for several minutes. The resulting precipitate was collected by filtration and washed with water and ethyl acetate to afford 4-(5-acetylaminomethylfuran-2-yl)-2-thioureidothiazole (2.95 g).

Workup

  1. customevaporation in vacuo
  2. additionthe residue was mixed with water (50 ml) and ethyl acetate (15 ml)
  3. stirringstirred for several minutes
  4. filtrationThe resulting precipitate was collected by filtration
  5. washwashed with water and ethyl acetate

Sources & evidence

ORD record
ord-e9a3a5caebf1450fa0721f7dc134efdc
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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