反应详情

A solution of 5-acetylaminomethyl-2-chloroacetylfuran (39.9 g) and diaminomethylenethiourea (21.9 g) in ethanol (400 ml) was refluxed for two hours with stirring. The solvent was evaporated in vacuo and the residue was dissolved in water (300 ml). The solution was basified with an aqueous potassium carbonate. The resulting precipitate was collected by filtration, washed with water and recrystallized from a mixture of methanol, tetrahydrofuran and diisopropyl ether to afford 4-(5-acetylaminomethylfuran-2-yl)-2-(diaminomethyleneamino)thiazole (24.1 g).

1. customThe solvent was evaporated in vacuo
2. dissolutionthe residue was dissolved in water (300 ml)
3. filtrationThe resulting precipitate was collected by filtration
4. washwashed with water
5. customrecrystallized from a mixture of methanol, tetrahydrofuran and diisopropyl ether