Hydrochloric Acid → HCID 15704156, compound

Participants

Reaction Steps

To this mixture was dropwise added a mixture of 4-(5-cyanomethylfuran-2-yl)-2-(diaminomethyleneamino)thiazole (16.0 g) in tetrahydrofuran (30 ml) for 30 minutes under ice-cooling and the mixture was stirred for an hour at ambient temperature. The reaction mixture was added to a mixture of ethyl acetate and water and the mixture was adjusted to pH 1 with 6N-hydrochloric acid. The separated aqueous layer was adjusted to pH 10 with 10% aqueous sodium hydroxide and the mixture was extraced with a mixture of tetrahydrofuran and ethyl acetate. The extract layer was washed with brine and dired over magnesium sulfate. The solvent was concentrated to give 4-[5-(2-aminoethyl)furan-2-yl]-2-(diaminomethyleneamino)thiazole (4.71 g).

Provenance & Evidence