Water → HCID 10039842, compound

Participants

Reaction Steps

A suspension of 2-(diaminomethyleneamino)-4-(5-guanidinocarbamoylfuran-2-yl-)thiazole sulfate (1.70 g) in concentrated ammonium hydroxide (17 ml) was refluxed with stirring. Additional ammonium hydroxide (8.5 ml) was added twice. After refluxing for 8 hours, water was added to the mixture and the resulting precipitate was collected by filtration, followed by recrystallization from aqueous N,N-dimethylformamide to afford 4-[5-(3-amino-1H-1,2,4-triazol-5-yl)furan-2-yl]-2-(diaminomethyleneamino)thiazole (0.73 g).

Provenance & Evidence