Sulfuric Acid → HCID 131718400, compound

HRID 1033064Notes

Reaction equation

HRID 1033064 reaction equation
[S:1](=[O:5])(=[O:4])([OH:3])[OH:2].[NH2:6][C:7](=[N:9][C:10]1[S:11][CH:12]=[C:13]([C:15]2[O:16][C:17]([CH2:20][NH:21][C:22]([NH2:24])=[O:23])=[CH:18][CH:19]=2)[N:14]=1)[NH2:8]>CO>[S:1]([OH:5])([OH:4])(=[O:3])=[O:2].[NH2:6][C:7](=[N:9][C:10]1[S:11][CH:12]=[C:13]([C:15]2[O:16][C:17]([CH2:20][NH:21][C:22]([NH2:24])=[O:23])=[CH:18][CH:19]=2)[N:14]=1)[NH2:8].[NH2:6][C:7](=[N:9][C:10]1[S:11][CH:12]=[C:13]([C:15]2[O:16][C:17]([CH2:20][NH:21][C:22]([NH2:24])=[O:23])=[CH:18][CH:19]=2)[N:14]=1)[NH2:8]

Participants

4

Reactant 2

HCID 1118Sulfuric AcidHCID 10446374HCID 10446374, compound

Product 1

HCID 131718400HCID 131718400, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A solution of conc. sulfuric acid (0.7 ml) in methanol (10 ml) was added to a mixture of 2-(diaminomethyleneamino)-4-(5-ureidomethylfuran-2-yl)thiazole (4.0 g) in methanol (60 ml) and the mixture was stirred for an hour at ambient temperature. The isolated precipitate was collected by filtration and the precipitate was recrystallized from an aqueous ethanol to give 2-(diaminomethyleneamino)-4-(5-ureidomethylfuran-2-yl)thiazole hemisulfate (4.26 g).

Workup

  1. filtrationThe isolated precipitate was collected by filtration
  2. customthe precipitate was recrystallized from an aqueous ethanol

Sources & evidence

ORD record
ord-406bb441ccb14fce82874e9b486dfdb3
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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