Hydrochloric Acid → HCID 178478808, compound

Participants

Reaction Steps

A solution of hydrogen chloride in methanol (0.19 g/ml, 3 ml) was added slowly to a suspension of 2-(diaminomethyleneamino)-4-(5-guanidinomethylfuran-2-yl)thiazole (500 mg) in methanol (10 ml) with cooling on an ice-water bath. The mixture was stirred with cooling on an ice-water bath for 2 hours. The mixture was diluted with diisopropyl ether (20 ml) and the resulting precipitate was collected by filtration. Recrystallization from a mixture of methanol, tetrahydrofuran and diisopropyl ether afforded 2-(diaminomethyleneamino)-4-(5-guanidinomethylfuran-2-yl)thiazole dihydrochloride (340 mg).

Provenance & Evidence