Methyl iodide → HCID 86747810, compound

HRID 1033071Notes

Reaction equation

HRID 1033071 reaction equation
[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][NH:16][C:17]([NH2:19])=[S:18])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3].[CH3:20][I:21]>CO>[IH:21].[NH2:1][C:2](=[N:4][C:5]1[S:6][CH:7]=[C:8]([C:10]2[O:11][C:12]([CH2:15][N:16]=[C:17]([NH2:19])[S:18][CH3:20])=[CH:13][CH:14]=2)[N:9]=1)[NH2:3]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 10357226HCID 10357226, compound

Product 1

HCID 86747810HCID 86747810, compoundYield 87.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A suspension of 2-(diaminomethyleneamino)-4-(5-thioureidomethylfuran-2-yl)thiazole (1.0 g) and methyl iodide (600 mg) in methanol was stirred at room temperature for 34 hours. The solvent was removed under reduced pressure to afford 2-(diaminomethyleneamino)-4-[5-(2-methyl-3-isothioureido)methylfuran-2-yl]thiazole hydriodide (1.3 g).

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-cf744074d9b24ab891a777dbc259d0c4
Source dataset
uspto-grants-1994_05
Patent number
US05308857

Reaction notes

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