Diisopropyl Ether → HCID 178503899, compound

Participants

Reaction Steps

A mixture of 4-(5-aminomethylfuran-2yl)-2-(diaminomethyleneamino)thiazole (8.00 g) and dimethyl-N-cyanodithioiminocarbonate (2.54 g) in ethanol (80 ml) was refluxed for two hours with stirring. After cooling to room temperature, diisopropyl ether (80 ml) was added and the resulting precipitate was collected filtration. Recrystallization from a mixture of N,N-dimethylformamide and ethyl acetate to give 2-(diaminomethyleneamino)-4-[5-(3-cyano-2-methyl-1-isothioureido)methylfuran-3-yl]thiazole (10.2 g).

Provenance & Evidence