Ethanol → HCID 86747815, compound

Participants

Reaction Steps

A mixture of chloroacetyl derivative from Step 3 (150 mg), Cs2CO3 (75 mg), thioacetic acid (30 μL) in EtOH (10 mL) was stirred at r.t. for 1 hr. The reaction mixture was diluted with Et2O, washed with pH 7 buffer solution, brine and the solvent evaporated. The residue was dissolved in MeOH, NaOMe (1M, 3 drops) and MeI (50 μL) was added. The mixture was stirred at r.t. for 3 hr. and diluted with a saturated NH4Cl solution and Et2O. The organic phase was separated, washed with H2O, brine, dried over MgSO4 and the solvent evaporated. The residue was flash chromatographed, eluting with hexane:EtOAc (85:15) to afford the title compound as a foam.

Provenance & Evidence