Hydrochloric Acid → HCID 19919781, compound

Participants

Reaction Steps

To a solution of methyl Z-4-[[2-butyl-5-[[1-butyl-2,5-dioxo-3-(2-thienylmethyl)-4-imidazolidinylidene]methyl]-1H-imidazol-1-yl]methyl]benzoate (0.70 g, 1.46 mmol) in warm DMF (10 mL) is added K2CO3 (2.0 g, 15 mmol). After stirring for 5 minutes 1-iodobutane (0.312 g, 1.7 mmol) is added. The mixture is stirred for 2 hours. The mixture is filtered and the filtrate is concentrated in vacuo and treated with water (20 mL) to afford a gum upon decantation. This gum is dissolved in ether and washed with water and then dried over K2CO3. A viscous oil is obtained by evaporation of the solvents in vacuo. This oil is dissolved in ether and treated with ethereal HCl to precipitate a gum which is collected by decantation. This gum is dissolved in warm ethanol and ether is added to induce crystallization. The crystals are collected and washed with ether.

Provenance & Evidence