HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4R)-4-phenyl-1,3-oxazolidin-2-one → HCID 53936034, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4R)-4-phenyl-1,3-oxazolidin-2-one | HCID 730425 | — |
| Reactant | Sodium bis(trimethylsilyl)amide | HCID 2724254 | — |
| Reactant | Benzyl 4-(bromomethyl)benzoate | HCID 18543917 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 53936034 | HCID 53936034 | — |
Reaction Steps
490 mg (3 mmol) of (4R)-(-)-4-phenyl-2-oxazolidinone are dissolved in 9 ml of absolute THF, first 3.3 ml of sodium bistrimethylsilylamide (1M in THF) and then 1050 mg (3.45 mmol) of benzyl 4-bromomethylbenzoate, dissolved in 2 ml of absolute THF, are added. The crude product is purified by chromatography (eluent: CH2Cl2)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05310499 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-a3d61c1e46124cb58c3911e178bf5086 |
| Source note | uspto-grants-1994_05 |