Water → HCID 19025376, compound

Participants

Reaction Steps

This compound was prepared in a manner analogous to that of Step D of Example 1, using 6.8 grams (0.013 mole) of 2-chloro-2-trifluoromethyl-3-[5-fluoro-2-nitro-4-(1-methyl-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedion-3-yl)phenyl]propanoic acid, 7.0 grams (0.130 g-atom) of iron powder, and 20 mL of water in 100 mL of acetic acid, yielding 3.2 grams of 3-(3-chloro-6-fluoro-3,4-dihydro-3-trifluoromethylquinolin-2-on-7-yl)-1-methyl-6-trifluoromethyluracil. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence