HuagongsheHuagongshe Chemistry Print Report · For research reference only
Catechol → 2-Ethyl-2-methyl-2H-1,3-benzodioxole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Catechol | HCID 289 | — |
| Reactant | Methyl Ethyl Ketone | HCID 6569 | — |
| Reactant | Phosphorus oxide (P4O10) | HCID 14812 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Ethyl-2-methyl-2H-1,3-benzodioxole | HCID 12608160 | — |
Reaction Steps
Following Intermediate Method 3, the reaction of catechol with 2-butanone and phosphorus pentoxide in methylene chloride produces 2-ethyl-2-methyl-1,3-benzodioxole, (XVI). Nitration of (XVI) with nitric and sulfuric acid in methylene chloride yields 2-ethyl-2-methyl-5-nitro-1,3-benzodioxole, (XVII). Subsequent hydrogenation of the compound (XVII) with platinum oxide in ethanol produces 5-amino-2-ethyl-2-methyl-1,3-benzodioxole, (XVIII). ##STR30##
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05310724 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-d4a2c283957342f69698cc36c704c909 |
| Source note | uspto-grants-1994_05 |