Methylhydrazine → HCID 19025425, compound

HRID 1033180Notes

Reaction equation

HRID 1033180 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]=[S:11])=[CH:5][CH:4]=1)#[N:2].[CH3:12][NH:13][NH2:14]>C(O)C>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10](=[S:11])[N:13]([CH3:12])[NH2:14])=[CH:7][CH:8]=1)#[N:2]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 17626Benzonitrile, 4-isothiocyanato-

Product 1

HCID 19025425HCID 19025425, compoundYield 98.9%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following procedures similar to those employed in Step A of Example 2, the reaction of 7.8 g (0.049 mole) of 4-cyanophenyl isothiocyanate with 2.24 g (0.049 mole) of methylhydrazine in 50 ml of ethanol yielded 10.0 g of 4-(4-cyanophenyl)-2-methyl-3-thiosemicarbazide as a solid, mp 178°-179° C. The nmr spectrum was consistent with the proposed structure.

Sources & evidence

ORD record
ord-1659086606ac4f5e94cc13d91721a20f
Source dataset
uspto-grants-1994_05
Patent number
US05310724

Reaction notes

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