Methylhydrazine → HCID 19025407, compound

HRID 1033182Notes

Reaction equation

HRID 1033182 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[C:4]([CH3:11])[CH:3]=1.[CH3:12][NH:13][NH2:14]>C(O)C>[I:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[S:10])[N:13]([CH3:12])[NH2:14])=[C:4]([CH3:11])[CH:3]=1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 19025388HCID 19025388, compound

Product 1

HCID 19025407HCID 19025407, compoundYield 64.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following procedures similar to those employed in Step A of Example 2, the reaction of 22.3 g (0.0810 mole) of 4-iodo-2-methylphenyl isothiocyanate with 3.74 g (0.0811 mole) of methylhydrazine in 175 ml of ethanol yielded 16.7 g of 4-(4-iodo-2-methylphenyl)-2-methyl-3-thiosemicarbazide as a solid, mp 160°-161° C. The nmr spectrum was consistent with the proposed structure.

Sources & evidence

ORD record
ord-d9c6781c698b410c832185b1ce682ab0
Source dataset
uspto-grants-1994_05
Patent number
US05310724

Reaction notes

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