Hydrochloric Acid → HCID 19025735, compound

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Reaction Steps

The resultant compound from Example 6A (4.66 g, 1.12 mol) was dissolved in methylene chloride and treated with gaseous HCl. The solution was evaporated and the residue was dissolved in methanol, treated with 10% Pd/C and hydrogenated under 50 psi hydrogen. The mixture was evaporated to afford 330 g (81%) of the desired product: 1H NMR (CDCl3) δ7.37-7.13 (m, 5H), 3.68 (s, 3H), 3.42 (dd, 1H), 3.29-3.18 (m, 1H), 3.18-3.12 (m, 4H), 3.07 (dd, 1H), 2.97-2.82 (m, 6H).

Provenance & Evidence