反应详情

A mixture of 12.9 g of 2-isopropylthiobenzoic acid chloride and 20 ml of absolute toluene is added dropwise at a temperature of from 15° to 20° C. to a mixture of 4.44 g of 3-hydroxy-oxetane, 6.64 g of pyridine and 60 ml of absolute toluene. The resulting suspension is stirred for 2 hours at a temperature of from 20° to 25° C. and for a further 3 hours at a temperature of from 40° to 45° C. Water is added to the reaction mixture and the organic phase is washed with water, dried and concentrated by evaporation to yield 12.6 g of 2-isopropylthiobenzoic acid oxetan-3-yl ester in the form of a pale yellow oil.

1. washthe organic phase is washed with water
2. customdried
3. concentrationconcentrated by evaporation