2-Chloro-4-fluoro-5-nitrothiobenzoic acid (methoxycarbonylmethyl) ester → 5-Amino-2-chloro-4-fluorothiobenzoic acid (methoxycarbonylmethyl) ester

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Reaction Steps

10.4 g of the resulting 2-chloro-4-fluoro-5-nitrothiobenzoic acid (methoxycarbonylmethyl) ester are hydrogenated with hydrogen under normal pressure in 150 ml of tetrahydrofuran at a temperature of from 20° to 25° C. in the presence of 2 g of Raney nickel catalyst. When the stoichiometric amount of hydrogen has been consumed, the catalyst is separated off and the solution is concentrated by evaporation to yield 8.6 g of 5-amino-2-chloro-4-fluorothiobenzoic acid (methoxycarbonylmethyl) ester having a melting point of from +88° to +89° C.

Provenance & Evidence