反应详情

Part B. The ester prepared in Part A above (14.4 g, 32.6 mmol) was stirred in ethanolic sodium hydroxide (240 mL, 0.25N, 60 mmol, about 5% water added) at ambient temperature for 48 hours. The reaction mixture was evaporated, neutralized to pH 7 with small portions of 1N aqueous hydrochloric acid, and saturated with sodium chloride. This mixture was extracted with ethyl acetate (2×200 mL), and the extracts were combined, dried over anhydrous magnesium sulfate, filtered and evaporated to afford 5-[4,5-bis(4-methoxyphenyl)-1H-imidazole-2-ylthio]pentanoic acid as a waxy solid (12.1 g, 29.3 mmol, 90%).

1. customThe reaction mixture was evaporated
2. extractionThis mixture was extracted with ethyl acetate (2×200 mL)
3. dry with materialdried over anhydrous magnesium sulfate
4. filtrationfiltered
5. customevaporated