Sodium Carbonate → HCID 15476622, compound

Participants

Reaction Steps

After 5 g of 5'-O-acetyl-3'-deoxy-3'-bromoadenosine (X) was dissolved in 100 ml of acetonitrile, 1.71 g of sodium carbonate (dissolved in 10 ml of water) and 1.5 g of Pd/C were added to the solution. The mixture was stirred at room temperature for 2 hours under hydrogen atmosphere of 3.5 atms. The reaction solution was filtered and the residue was washed with ethyl acetate. The filtrate was combined with the washing liquid. After the organic solvent was distilled off under reduced pressure, the formed crystals were taken out by filtration. The crystals were dissolved in 200 ml of ethyl acetate. The solution was dried over magnesium sulfate and the drying agent was removed. The system was concentrated to give 2.7 g (yield, 69%) of 3'-deoxy-5'-O-acetyladenosine (XII).

Provenance & Evidence