HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 57074370, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Quinaldic Acid | HCID 7124 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | (2R*,4S*)-2-Benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine | HCID 57202094 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | HCID 57074370 | HCID 57074370 | — |
Reaction Steps
97 mg (0.56 mmol) of quinoline-2-carboxylic acid are reacted in analogy to Example 2j first with 58 μl (0.795 mmol) of thionyl chloride and subsequently with 200 mg (0.468 mmol) of (2R*,4S*)-2-benzyl-N-(4-quinolylmethyl)-N-trifluoroacetyl-4-piperidinamine to give the product. TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.45, FD-MS: M+ =582.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05310743 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-0ca9ff4fbec04ee59f2e8ce4b2ccbd13 |
| Source note | uspto-grants-1994_05 |