Cyclohexyl isocyanate → HCID 57128561, compound

HRID 1033348Notes

Reaction equation

HRID 1033348 reaction equation
[CH2:1]([C@H:8]1[CH2:13][C@H:12]([NH:14][CH2:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=[CH:18][CH:17]=2)[CH2:11][CH2:10][N:9]1[C:26](=[O:35])[C:27]1[CH:32]=[C:31]([Cl:33])[CH:30]=[C:29]([Cl:34])[CH:28]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:36]1([N:42]=[C:43]=[O:44])[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]1>>[CH2:1]([C@@H:8]1[CH2:13][C@@H:12]([N:14]([CH2:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[N:19]=[CH:18][CH:17]=2)[C:43](=[O:44])[NH:42][CH:36]2[CH2:41][CH2:40][CH2:39][CH2:38][CH2:37]2)[CH2:11][CH2:10][N:9]1[C:26](=[O:35])[C:27]1[CH:28]=[C:29]([Cl:34])[CH:30]=[C:31]([Cl:33])[CH:32]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 18502Cyclohexyl isocyanateHCID 67726981HCID 67726981, compound

Product 1

HCID 57128561HCID 57128561, compound

Procedure

200 mg (0.396 mmol) of (2S*,4R*)-2-benzyl-1-(3,5-dichlorobenzoyl)-N-(4-quinolylmethyl)-4-piperidinamine are reacted with 66 μl (0.515 mmol) of cyclohexyl isocyanate in analogy to Example 16a. The title compound ##STR79## is obtained as white crystals (165 mg, 66%) of melting point 229° C. (decomposition). TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.44, FD-MS: M+ =628, 630.

Sources & evidence

ORD record
ord-23d2dd6fd6c74271a63c7106d57ebb0b
Source dataset
uspto-grants-1994_05
Patent number
US05310743

Reaction notes

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