2-Methoxybenzaldehyde → HCID 57073059, compound

Participants

Reaction Steps

200 mg (0.551 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine are reacted in analogy to Example 2g with 75 mg (0.551 mmol) of 2-methoxybenzaldehyde and 90 mg magnesium sulfate in 2 ml of toluene and subsequently reduced with 22 mg (0.584 mmol) of sodium borohydride in 2 ml of methanol. The title compound ##STR91## is obtained (170 mg, 64%) as white foam. TLC: methylene chloride/methanol/conc. ammonia (700:50:1) Rf =0.66, FD-MS: M+ =482, 482. IR: 1620 cm-1.

Provenance & Evidence