Sulfuric acid magnesium salt (1:1) → HCID 57307820, compound

Participants

Reaction Steps

200 mg (0.551 mmol) of (2R*,4S*)-2-benzyl-1-(3,5-dichlorobenzoyl)-4-piperidinamine are reacted in analogy to Example 2g with 97 mg (0.661 mmol) of benzofuran-2-carboxaldehyde and 90 mg of magnesium sulfate in 2 ml of toluene and subsequently reduced with 22 mg (0.584 mmol) of sodium borohydride in 2 ml of methanol. The title compound ##STR93## is obtained (150 mg, 55%) as oil. TLC: methylene chloride/methanol/conc. ammonia (2000:50:1) Rf =0.18, FD-MS: M+ =492, 494. IR: 1630 cm-1.

Provenance & Evidence