Hydrochloric Acid → HCID 178479237, compound

Participants

Reaction Steps

The intermediate obtained in Step C (109 mg, 0.196 mmol) was dissolved in 2 mL of methanol and treated with 0.1 mL of concentrated hydrochloric acid. The reaction mixture was stirred at room temperature for 16 hours then solvents were removed under vacuum and the residue redissolved in water and washed with ethyl acetate. The aqueous layer was separated and the solvent removed under vacuum to yield 87 mg (0.17 mmol, 88%) of the title compound. 1H NMR (200 MHz, CD3OD): 2.10 (m, 1 H), 2.48 (m, 3 H), 3.68 (s,2 H), 4.37 (m,1 H), 4.84 (d,14 Hz,1 H), 5.22 (d,14 Hz,1 H), 6.9-7.7 (m,12 H). FAB-MS: calculated for C26H25N7O2 467; found 468 (M+H,100%).

Provenance & Evidence