3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid → HCID 19025722, compound

HRID 1033386Notes

Reaction equation

HRID 1033386 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][C:26]([I:28])=[CH:27][C:20]=2[NH:19][C:18]1=[O:29]>>[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][C:26]([I:28])=[CH:27][C:20]=2[NH:19][C:18]1=[O:29])=[O:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 103760463-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acidHCID 54038938HCID 54038938, compound

Product 1

HCID 19025722HCID 19025722, compound

Procedure

Prepared from 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) and the amine obtained in Step E by the procedure described in Example 1, Step F. 1H NMR (200MHz, CDCl3): 1.33 (s,6H), 1.42 (s,9H), 1.80(m,1H), 2.24 (m,2H), 2.50 (m,3H), 4.45 (m,1H), 6.98 (d,8Hz,1H), 7.35 (d,2Hz,1H), 7.43 (dd;2,8Hz;1H). FAB-MS: calculated for C20H28IN3O4 501; found 502 (M+H,20%).

Sources & evidence

ORD record
ord-44babc1a3938467bb4b5aac2e93e50d5
Source dataset
uspto-grants-1994_05
Patent number
US05310737

Reaction notes

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