3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid → HCID 19025472, compound

HRID 1033393Notes

Reaction equation

HRID 1033393 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][C:26]([Cl:28])=[CH:27][C:20]=2[NH:19][C:18]1=[O:29]>>[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([NH:16][CH:17]1[CH2:23][CH2:22][C:21]2[CH:24]=[CH:25][C:26]([Cl:28])=[CH:27][C:20]=2[NH:19][C:18]1=[O:29])=[O:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 103760463-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acidHCID 19025701HCID 19025701, compound

Product 1

HCID 19025472HCID 19025472, compound

Procedure

Prepared from 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) and the amine obtained in Step F by the procedure described in Example 1, Step F. 1H NMR (300MHz, CDCl3): 1.35 (s,6H), 1.42 (s,9H), 1.95 (m,1H), 2.4-2.8 (m,5H), 4.51 (m,1H), 5.22 (br s,1H), 6.73 (d,7Hz,1H), 7.02 (s,1H), 7.14 (br s,2H), 8.21 (br s,1H). FAB-MS: calculated for C20H28C1N3O4 409; found 410 (M+H,55%).

Sources & evidence

ORD record
ord-3af2780735854de2a5efee3f986fb99d
Source dataset
uspto-grants-1994_05
Patent number
US05310737

Reaction notes

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