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HRID 1033399作成日：2026年10月25日

3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one → 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide

https://huagongshe.com/reaction/1033399

反応式

関与物質

役割名称HCID仕込み量
反応物3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-oneHCID 4434433—
反応物3-(((Benzyloxy)carbonyl)amino)-3-methylbutanoic acidHCID 14551007—
生成物3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamideHCID 21836609—

反応手順

Prepared from 3-amino-2,3,4,5-tetrahydro-1H[1]benzazepin-2-one (Example 1, Step A) and 3-benzyloxycarbonylamino-3-methylbutanoic acid (Example 1, Step E) by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CDCl3): 1.38 (s,3H), 1.39 (s,3H), 1.82 (m,1H), 2.52 (s,2H), 2.5-3.0 (m,3H), 4.51 (m,1H), 5.07 (br s,2H), 5.58 (br s,1H), 6.68 (d,7 Hz, 1H), 6.96 (d,8 Hz, 1H), 7.1-7.4 (m,8H), 7.62 (br s, 1H). FAB-MS: calculated for C23H27N3O4 409; found 410 (M+H,100%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05310737
出典データセットuspto-grants-1994_05
ORD IDord-d2a7dd0ed1594b2f8ba7ab5593f671ab
出典メモuspto-grants-1994_05