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HRID1033400

反应详情

EQUATION

反应方程式

HRID 1033400 的结构方程式

REACTANTS

反应物

2
结构：N[C@@H]1CCc2ccccc2NC1=O
HCID10103689

(3R)-3-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one

C10H12N2O

结构：CC(C)(CC(=O)O)NC(=O)OC(C)(C)C
HCID10376046

3-[(tert-Butoxycarbonyl)amino]-3-methylbutanoic acid

C10H19NO4

PRODUCTS

生成物

1
结构：CC(C)(CC(=O)N[C@@H]1CCc2ccccc2NC1=O)NC(=O)OC(C)(C)C
HCID10474604

3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide

C20H29N3O4

PROCEDURE

实验过程

Prepared from 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) and 3(R)-amino-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (Example 1, Step B) by the procedure described in Example 1, Step F. 1H NMR (200 MHz, CDCl3): 1.37 (s,6H), 1.44 (s,9H), 1.95 (m,1H), 2.46 (d,15 Hz, 1H), 2.59 (d,15 Hz, 1H), 2.6-3.0, (m,3H), 4.53 (m,1H), 5.30 (br s,1H), 6.72 (d,7 Hz, 1H), 6.98 (d,8 Hz,1H), 7.1-7.3 (m,3H), 7.82 (br s,1H). FAB-MS: calculated for C20H29N3O4 375; found 376 (M+H,70%).