3-Amino-2,3,4,5-tetrahydro-1H-benzazepin-2-one → 3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide

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Reaction Steps

Prepared from 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) and 3-amino-2,3,4,5-tetrahydro-1H-1-benzazepin-2-one (Example 1, Step A) by the procedure described in Example 1, Step F. 1H NMR (300 MHz, CDCl3): 1.34 (s,6H), 1.41 (s,9H), 1.90 (m,1H), 2.45 (d,15 Hz, 1H), 2.56 (d,15 Hz, 1H), 2.65 (m,1H), 2.76 (m,1H), 2.92 (m,1H), 4.53 (m,1H), 5.20 (br s,1H), 6.62 (d,15 Hz, 1H), 6.97 (d,8 Hz, 1H), 7.10-7.25 (m,3H), 7.35 (br s,1H). FAB-MS: calculated for C20H29N3O4 375; found 376 (M+H,45%).

Provenance & Evidence