3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid → HCID 18651487, compound

HRID 1033407Notes

Reaction equation

HRID 1033407 reaction equation
[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([OH:13])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH3:16][NH:17][C@@H:18]1[CH2:24][CH2:23][C:22]2[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=2[NH:20][C:19]1=[O:29]>>[C:1]([O:5][C:6]([NH:8][C:9]([CH3:15])([CH3:14])[CH2:10][C:11]([N:17]([CH3:16])[C@@H:18]1[CH2:24][CH2:23][C:22]2[CH:25]=[CH:26][CH:27]=[CH:28][C:21]=2[NH:20][C:19]1=[O:29])=[O:13])=[O:7])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 103760463-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acidHCID 18651474HCID 18651474, compound

Product 1

HCID 18651487HCID 18651487, compound

Procedure

Prepared from 3-t-butoxycarbonylamino-3-methylbutanoic acid (Example 31, Step E) and the amine obtained in Step B by the produce described in Example 1, Step F. 1H NMR (200MHz, CDCl3): 1.30 (br s,15H), 2.19 (m,1H), 2.42 (m,1H), 2.5-2.8 (m,3H), 2.91 (m,1H), 3.15 (s,3H), 5.32 (dd;6,8Hz;1H), 5.52 (br s,1H), 6.97 (d,5Hz,1H), 7.1-7.3 (m,3H), 7.35 (br s,1H).

Sources & evidence

ORD record
ord-15afb67b19504be798b3c0f9cdb633c8
Source dataset
uspto-grants-1994_05
Patent number
US05310737

Reaction notes

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