Benzylamine → HCID 67751885, compound

HRID 1033417Notes

Reaction equation

[CH3:1][C:2]([NH:36][C:37]([O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)=[O:38])([CH3:35])[CH2:3][C:4]([NH:6][C@@H:7]1[CH2:13][CH2:12][C:11]2[CH:14]=[CH:15][CH:16]=[CH:17][C:10]=2[N:9]([CH2:18][C:19]2[CH:24]=[CH:23][C:22]([C:25]3[C:26]([C:31]([OH:33])=O)=[CH:27][CH:28]=[CH:29][CH:30]=3)=[CH:21][CH:20]=2)[C:8]1=[O:34])=[O:5].[CH2:47]([NH2:54])[C:48]1[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1>>[C:48]1([CH2:47][NH:54][C:31]([C:26]2[C:25]([C:22]3[CH:21]=[CH:20][C:19]([CH2:18][N:9]4[C:10]5[CH:17]=[CH:16][CH:15]=[CH:14][C:11]=5[CH2:12][CH2:13][C@@H:7]([NH:6][C:4](=[O:5])[CH2:3][C:2]([NH:36][C:37]([O:39][CH2:40][C:41]5[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=5)=[O:38])([CH3:1])[CH3:35])[C:8]4=[O:34])=[CH:24][CH:23]=3)=[CH:30][CH:29]=[CH:28][CH:27]=2)=[O:33])[CH:53]=[CH:52][CH:51]=[CH:50][CH:49]=1

Participants

Reactant 2

HCID 7504Benzylamine

HCID 67751249HCID 67751249, compound

Product 1

HCID 67751885HCID 67751885, compound

Procedure

The title compound was prepared from 4'-[[2,3,4,5-tetrahydro-3(R)-[[3-methyl-1-oxo-3-[(benzyloxycarbonyl)amino]butyl]amino-]-2-oxo-1H-1-benzazepin-1yl]methyl][1,1'-biphenyl]-2-carboxylic acid (Example 72, Step B) and benzylamine according to the procedure described in Example 74, Step A. 1H NMR (200 MHz,CDCl3): 1.31 (s,3H), 1.35 (s,3H), 1.75 (m,1H), 2.30-2.65 (m,5H), 4.23 (d,5 Hz,2H), 4.47 (m,1H), 4.83 (d,14 Hz,1H), 5.02 (s,2H), 5.45 (m,1H), 5.60 (s,1H), 6.68 (d,6Hz,1H), 6.90 (m,2H), 7.10-7.50 (m,20H), 7.65 (m,1H). FAB-MS: calculated for C44H44N4O5 708; found 709 (M+H), 731 (M+Na, 100%).

Sources & evidence

ORD record: ord-a07ef206c3384fbf982591c4deece0fd
Source dataset: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05310737

Reaction notes

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