HRID1033426

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(CC(=O)N[C@@H]1CCc2ccccc2NC1=O)NC(=O)OC(C)(C)C

HCID10474604

3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide

C20H29N3O4

HCID54127297

未命名化合物

PRODUCTS

生成物

结构：CC(=O)OCC(=O)c1ccccc1-c1ccc(CN2C(=O)[C@H](NC(=O)CC(C)(C)NC(=O)OC(C)(C)C)CCc3ccccc32)cc1

HCID57171169

未命名化合物

PROCEDURE

实验过程

Prepared from 4'-bromoethyl-2-(acetoxyacetyl) -1,1'-biphenyl and 3-t-butoxycarbonylamino-3-methyl -N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide (Example 57, Step A) by the procedure described in Example 69, Step D. 1H NMR (200 MHz,CDCl3): 1.33 (s,6H), 1.39 (s,9H), 1.87 (m,1H), 2.03 (s,3H), 2.35-2.70 (m,5H), 4.36 (s,2H), 4.51 (m,1H), 4.85 (d,15 Hz,1H), 5.28 (d,15 Hz,1H), 6.66 (m,1H), 7.1-7.6 (m,12H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-23a0985d707145ee8d7f3eca91a53a13
来源数据集: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05310737
来源说明: uspto-grants-1994_05

反应 SMILES

BrC[CH2:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[C:16](=[O:22])[CH2:17][O:18][C:19](=[O:21])[CH3:20])=[CH:6][CH:5]=1.[C:23]([O:27][C:28]([NH:30][C:31]([CH3:49])([CH3:48])[CH2:32][C:33]([NH:35][C@@H:36]1[CH2:42][CH2:41][C:40]2[CH:43]=[CH:44][CH:45]=[CH:46][C:39]=2[NH:38][C:37]1=[O:47])=[O:34])=[O:29])([CH3:26])([CH3:25])[CH3:24]>>[C:19]([O:18][CH2:17][C:16]([C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=1[C:7]1[CH:6]=[CH:5][C:4]([CH2:3][N:38]2[C:39]3[CH:46]=[CH:45][CH:44]=[CH:43][C:40]=3[CH2:41][CH2:42][C@@H:36]([NH:35][C:33](=[O:34])[CH2:32][C:31]([NH:30][C:28](=[O:29])[O:27][C:23]([CH3:25])([CH3:24])[CH3:26])([CH3:48])[CH3:49])[C:37]2=[O:47])=[CH:9][CH:8]=1)=[O:22])(=[O:21])[CH3:20]