HRID1033429

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(CC(=O)N[C@@H]1CCc2ccccc2NC1=O)NC(=O)OC(C)(C)C

HCID10474604

3-t-butoxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide

C20H29N3O4

结构：O=[N+]([O-])c1ccc(Oc2ccccc2-c2ccc(CCBr)cc2)cc1

HCID54141217

未命名化合物

PRODUCTS

生成物

结构：CC(C)(CC(=O)N[C@@H]1CCc2ccccc2N(Cc2ccc(-c3ccccc3[N+](=O)[O-])c(Oc3ccccc3)c2)C1=O)NC(=O)OC(C)(C)C

HCID131718402

未命名化合物

PROCEDURE

实验过程

Prepared from 4'-bromoethyl-2-(4-nitrophenoxy) -1,1'-biphenyl and 3-t-butoxycarbonylamino-3-methyl -N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-(R) -yl]-butanamide (Example 57, Step A) by the procedure described in Example 69, Step D. 1NMR (200 MHz, CDCl3): 1.32 (s,6H), 1.38 (s,9H), 1.78 (m,1H), 2.3-2.7 (m,5H), 4.47 (m,1H), 4.75 (d,15 Hz,1H), 5.13 (d,15 Hz,1H), 6.63 (d,7 Hz,1H), 6.75 (d,8 Hz,2H), 7.05-7.50 (m,/11H), 7.97 (s,1H), 7.98 (d,8 Hz,2H).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a730f94af2f147009082b756213500c8
来源数据集: uspto-grants-1994_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05310737
来源说明: uspto-grants-1994_05

反应 SMILES

BrCCC1C=CC([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[O:16][C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-:25])=[O:24])=[CH:19][CH:18]=2)=CC=1.[C:26]([O:30][C:31]([NH:33][C:34]([CH3:52])([CH3:51])[CH2:35][C:36]([NH:38][C@@H:39]1[CH2:45][CH2:44][C:43]2[CH:46]=[CH:47][CH:48]=[CH:49][C:42]=2[NH:41][C:40]1=[O:50])=[O:37])=[O:32])([CH3:29])([CH3:28])[CH3:27]>>[N+:23]([C:20]1[CH:19]=[CH:22][CH:17]=[CH:18][C:21]=1[C:22]1[CH:15]=[CH:10][C:11]([CH2:12][N:41]2[C:42]3[CH:49]=[CH:48][CH:47]=[CH:46][C:43]=3[CH2:44][CH2:45][C@@H:39]([NH:38][C:36](=[O:37])[CH2:35][C:34]([NH:33][C:31](=[O:32])[O:30][C:26]([CH3:29])([CH3:27])[CH3:28])([CH3:52])[CH3:51])[C:40]2=[O:50])=[CH:18][C:17]=1[O:16][C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:10]=1)([O-:25])=[O:24]