4'-(Bromomethyl)-2-cyanobiphenyl → 3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-cyano-[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide

Participants

Role	Name	HCID	Charge
Reactant	4'-(Bromomethyl)-2-cyanobiphenyl	HCID 1501912	—
Reactant	3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl]-butanamide	HCID 21836609	—
Product	3-Benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1-[[2'-cyano-[1,1'-biphenyl]-4-yl]methyl]-1H-1-benzazepin-3-yl]-butanamide	HCID 19025708	—

Reaction Steps

Prepared from 3-benzyloxycarbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3-yl ]-butanamide (Example 51, Step A) and 4'-bromomethyl-1,1'-biphenyl-2-nitrile (Example 69, Step C) by the procedure described in Example 1, Step K. FAB-MS: calculated for C37H36N4O4 600; found; 601 (M+H,100%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US05310737
Source dataset	uspto-grants-1994_05
ORD ID	ord-28c33a2d369b47b09497ffc31fdb2173
Source note	uspto-grants-1994_05