3-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acid → HCID 19025570, compound

HRID 1033451Notes

Reaction equation

HRID 1033451 reaction equation
[NH2:1][CH:2]1[CH2:8][CH2:7][C:6]2[CH:9]=[C:10]([S:13][CH3:14])[CH:11]=[CH:12][C:5]=2[NH:4][C:3]1=[O:15].[C:16]([O:20][C:21]([NH:23][C:24]([CH3:30])([CH3:29])[CH2:25][C:26](O)=[O:27])=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([NH:23][C:24]([CH3:30])([CH3:29])[CH2:25][C:26]([NH:1][CH:2]1[CH2:8][CH2:7][C:6]2[CH:9]=[C:10]([S:13][CH3:14])[CH:11]=[CH:12][C:5]=2[NH:4][C:3]1=[O:15])=[O:27])=[O:22])([CH3:19])([CH3:18])[CH3:17]

Participants

3

Reactant 2

HCID 103760463-((tert-Butoxycarbonyl)amino)-3-methylbutanoic acidHCID 19025652HCID 19025652, compound

Product 1

HCID 19025570HCID 19025570, compound

Procedure

Prepared from the intermediate obtained in Step D and 3-t-butoxycarbonylamino-3-methyl-butanoic acid (Example 31, Step E) by the procedure described in Example 1, Step F. 1H NMR (200MHz,CDCl3): 1.33 (s,6H), 1.40 (s,9H), 1.91 (m,1H), 2.4-3.0 (m,5H), 2.48 (s,3H), 4.50 (m,1H), 5.22 (br, s1H), 6.68 (d,7Hz,1H), 6.90 (d,8Hz,1H), 7.11 (m,2H), 7.66 (br, s,1H).

Sources & evidence

ORD record
ord-b825c8446ea442289f924d6970c76b00
Source dataset
uspto-grants-1994_05
Patent number
US05310737

Reaction notes

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