HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethyl Sulfoxide → 3-acetoxy-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethyl Sulfoxide | HCID 679 | — |
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 2,3-dihydro-3-hydroxy-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one | HCID 13652735 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 3-acetoxy-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one | HCID 19026141 | 70.6% |
Reaction Steps
A mixture of 2,3-dihydro-3-hydroxy-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one (30.0 g), acetic anhydride (50 ml), dimethylsulfoxide (100 ml), pyridine (3 ml) and toluene (100 ml) is stirred at room temperature for 4 days, and the mixture is treated in the same manner as in Reference Example 1-(1) to give 3-acetoxy-8-methyl-2-(4-methylphenyl)-1,5-benzothiazepin-4(5H)-one (24.0 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05310904 |
| Source dataset | uspto-grants-1994_05 |
| ORD ID | ord-483be5c1f65b4e268e9d73ed832c6dd7 |
| Source note | uspto-grants-1994_05 |