反应详情

温度

50 °C

The product, thiabendazole, precipitated as it was formed in the reaction mixture. The reaction was monitored by gas chromatography and determined to be complete when the peaks corresponding to o-phenylenediamine and 4-cyanothiazole were negligible. The reaction mass was allowed to cool to 50° C. and 150 ml of 50° C. deionized water was added to thin the mixture before being vacuum filtered using a medium fritted glass filter. The solid product was washed four times with 300 ml portions of deionized water. The washed precipitate was dried overnight in a vacuum oven under 15-20" Hg and at a temperature of 80°-90° C. A total of 89.77 grams of thiabendazole were obtained which corresponds to an 89.3% yield. The color of dry thiabendazole was cream. High Performance Liquid Chromatography (HPLC) using a Hewlett-Packard Model 1090M showed that the purity was 98.77% (based on % area).

1. customThe product, thiabendazole, precipitated as it
2. customwas formed in the reaction mixture
3. custom150 ml of 50° C.
4. additionwas added
5. filtrationfiltered
6. filtrationfilter
7. washThe solid product was washed four times with 300 ml portions of deionized water
8. customThe washed precipitate was dried overnight in a vacuum oven under 15-20" Hg and at a temperature of 80°-90° C