Dimethyl Sulfoxide → HCID 54359763, compound

Participants

Reaction Conditions

Reaction Steps

A mixture comprising 15.4 g of 1-(2,2-diphenylvinyl)-2-nitroiminoimidazolidine, 8.1 g of 2-chloro-5-chloromethylpyridine, 6.9 g of potassium carbonate and 80 ml of dimethylsulfoxide was stirred at 60° C. for 2 hours. The reaction mixture was poured into water, extracted with ethyl acetate, washed with water, dried (with anhydrous MgSO4) and concentrated to give a crude product. To this was added 100 ml of ethyl acetate for recrystallization, and 13 g of 1-(2-chloropyridin-5-ylmethyl)-2-nitroimino-3-(2,2-diphenylvinyl)imidazolidine was obtained.

Provenance & Evidence